An examination of the blood shows teardrop-shaped red blood cells. Bone marrow biopsy is usually needed to make the diagnosis and to rule out other causes of the symptoms.
In the past, the treatment of myelofibrosis has depended on the symptoms and degree of the low blood counts.
In young people, bone marrow or stem cell transplants appear to improve the outlook, and may cure the disease. A long-term (5 year) remission is possible for some patients with bone marrow transplantation. Such treatment should be considered for younger patients and some others.
Other treatment may involve:
Blood transfusions and medicines to correct anemia
Call for an appointment with your health care provider if symptoms of this disorder develop. Uncontrolled bleeding, shortness of breath, or jaundice that gets worse need urgent or emergency care.
There is no known prevention.
Tefferi A. Polycythemias, essential thrombocythemia, and primary myelofibrosis. In Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 169.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.